A High-Throughput Screen for Yeast Replicative Lifespan Identifies Lifespan-Extending Compounds
نویسندگان
چکیده
منابع مشابه
Chronological and replicative lifespan in yeast
Budding yeast is a preeminent model organism in studies of cellular aging pathways that are conserved in eukaryotes, including humans. There are two primary ways to query the lifespan of this organism.1 if one asks how many times a cell can divide, the answer will be its replicative lifespan (RLS). if, on the other hand, one asks how long a cell can stay alive without dividing, the answer will ...
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In the budding yeast Saccharomyces cerevisiae, loss of mitochondrial DNA (rho(0)) can induce the retrograde response under appropriate conditions, resulting in increased replicative lifespan (RLS). Although the retrograde pathway has been extensively elaborated, the nature of the mitochondrial signal triggering this response has not been clear. Mitochondrial membrane potential (MMP) was severel...
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Sgf73, a core component of SAGA, is the yeast orthologue of ataxin-7, which undergoes CAG-polyglutamine repeat expansion leading to the human neurodegenerative disease spinocerebellar ataxia type 7 (SCA7). Deletion of SGF73 dramatically extends replicative lifespan (RLS) in yeast. To further define the basis for Sgf73-mediated RLS extension, we performed ChIP-Seq, identified 388 unique genomic ...
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Increasing age is a risk factor for many diseases; therefore developing pharmacological interventions that slow down ageing and consequently postpone the onset of many age-related diseases is highly desirable. In this work we analyse data from the DrugAge database, which contains chemical compounds and their effect on the lifespan of model organisms. Predictive models were built using the machi...
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1Department of Biology, MIT, Cambridge, MA 02139, Howard Hughes Medical Institute, MIT, Cambridge, MA 02139; Whitehead Institute for Biomedical Research, Cambridge MA 02142, Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, MA 02142,The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA 2Department of Physiology, Institute for Diabetes,...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2017
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2017.11.002